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January 16, 1943


JAMA. 1943;121(3):194-195. doi:10.1001/jama.1943.02840030032010

The possibility of aborting experimental poliomyelitis in monkeys by the prophylactic or therapeutic injection of a second neurotropic virus has been suggested by Jungeblut and Sanders1 of the Department of Bacteriology, Columbia University. Two years ago they adapted the New Haven strain of poliomyelitis virus to white mice by intermediary passage through cotton rats.2 Thus adapted the virus lost most of its original pathogenicity for monkeys. When it was injected intravenously into monkeys the murine virus was electively localized in the central nervous system, where it persisted for relatively long periods of time without producing symptoms. On recovery from this subclinical infection the monkeys had hardly any acquired immunity against subsequent inoculation with virulent strains of poliomyelitis. This nonpathogenic mutant of virus from monkeys has been propagated for two hundred passage generations in mice, during which time it has increased a thousand fold in pathogenicity for mice with