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May 25, 1935


Author Affiliations

From the Department of Anatomy, Yale University School of Medicine.

JAMA. 1935;104(21):1901-1905. doi:10.1001/jama.1935.92760210006009a

Recently the process of menstruation has been observed microscopically in the living animal by Markee.1 This was accomplished by transplanting small pieces of endometrium into the anterior chamber of the eye, where they became vascularized and could be observed frequently for considerable periods. A graphic description of the onset and course of menstruation helps to vivify impressions of this hemorrhagic process as drawn from previous descriptions of histologic specimens.2

OBSERVATIONS ON THE MENSTRUATING ENDOMETRIUM  The main features may be summarized as follows: Endometrial transplants were observed in the eyes of six monkeys. Vasoconstriction began from six to twelve hours before the onset of menstruation and persisted throughout the first day. Menstruation began in the endometrium implanted in the eye, sometimes three hours before blood from the uterine hemorrhage entered the vagina. When several transplants were made into the same eye, the onset of menstruation was not simultaneous in all.