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January 23, 1943


JAMA. 1943;121(4):237-240. doi:10.1001/jama.1943.02840040013004

In 1920 Mook and Wander1 described the occurrence of painful, tender, slowly growing tumors in 6 patients who had been previously subjected to serious operations and had received camphor in oil injections as a stimulant. Several similar cases have since come under our care and we have seen others in clinical meetings in various cities throughout the country. In all of the cases seen the camphor oil injections had been made many years previous to our observation. Pharmaceutical houses, since the publication of Mook and Wander's report, have generally discontinued the sale of camphor and other drugs dissolved in liquid petrolatum. We have been watching for tumors due to the injection of other oils, because we knew that Burrows and Johnston2 were able to produce oil tumors in rats by the subcutaneous injection of corn oil. The tumors which they produced did not show as much cellular reaction