The introduction of the use of sulfonamide compounds as prophylactic and curative agents in the field of surgery has not been an unmitigated blessing for surgeons because of a growing tendency to neglect fundamental principles of good surgical judgment and technic and to rely instead on the wholesale use of the "wonder drugs." This undesirable condition has been brought about by a false impression that the sulfonamide compounds are "cure-alls" and represents a current trend toward an ignorant complacency in respect to the elective and selective uses of these agents.
There can be no questioning the fact that these drugs have frequently saved the patient of the careless surgeon from disaster, but when the sulfonamides fail because of neglect of the use of sound judgment and surgical technic, coupled with a lack of knowledge of the fundamental principles of sulfonamide therapy, then too often these drugs are berated as being
LONG PH. SULFONAMIDE COMPOUNDS IN THE PREVENTION AND TREATMENT OF WOUND INFECTION: A CONSIDERATION OF THE PRINCIPLES WHICH GOVERN THEIR USE. JAMA. 1943;121(5):303–307. doi:10.1001/jama.1943.02840050001001
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