Histologic studies of the central nervous system in dementia praecox have failed to reveal specific morphologic nerve changes. Such structural changes as may be present in this morbid condition are secondary. Quite constant, but by no means characteristic, are changes in the cerebral subarachnoid space. The changes may be termed chronic aseptic meningitis in which, among other lesions, there are present hyperplasia of the connective tissue and proliferation of the mesothelial cells. In addition, abnormal microchemical phenomena are demonstrable in the ganglion and glia cells, mainly in the form of lipoids. The aseptic meningitis is to be looked on as a meningeal reaction against toxic substances discharged from the depth of the brain tissues into the subarachnoid space. Though toxins are present also in normal cerebral tissues, they are probably neutralized after they have been removed by the tissue fluids of the brain into the subarachnoid space (by way of
HASSIN GB, BRODER SB. INTRAVENOUS INJECTIONS OF HYPOTONIC AND HYPERTONIC SOLUTIONS: THEIR THERAPEUTIC VALUE IN THE TREATMENT OF SOME MENTAL DISORDERS. JAMA. 1935;104(22):1955–1957. doi:10.1001/jama.1935.02760220001001
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