[Skip to Content]
[Skip to Content Landing]
Article
January 30, 1943

THE SODIUM SALTS OF SULFAPYRIDINE, SULFATHIAZOLE AND SULFADIAZINE: THEIR CLINICAL USE BY HYPODERMOCLYSIS

Author Affiliations

MEDICAL CORPS, ARMY OF THE UNITED STATES; MEDICAL CORPS, ARMY OF THE UNITED STATES; ROCHESTER, N. Y.

From the Department of Medicine, University of Rochester School of Medicine and Dentistry, and the Medical Clinics of the Strong Memorial and Rochester Municipal hospitals.

JAMA. 1943;121(5):313-315. doi:10.1001/jama.1943.02840050011003
Abstract

In a previous communication from this clinic1 the use of sodium sulfapyridine by hypodermoclysis was discussed. Our purpose in this paper is to describe in more detail our experience with the subcutaneous use of the sodium salts of sulfathiazole and sulfadiazine in addition to that of sulfapyridine and to emphasize that these drugs may be administered safely and conveniently by hypodermoclysis. During the past three years the aforementioned sulfonamide compounds have been administered by this route in 160 cases of pneumonia and other conditions for which this group of drugs was indicated but in which oral administration was difficult or impossible. More recently concentrations of these drugs in the blood have been followed at frequent intervals after hypodermic administration in 19 of these cases. The results of these studies are presented here.

METHOD OF PREPARATION AND ADMINISTRATION OF SULFONAMIDE SOLUTIONS  The majority of the patients were treated with 0.5

×