In Reply Drs Miller and Sittig challenge our claim that the big ideas that have long dominated biomedical research have underperformed. Interestingly, they admit that morbidity and mortality can be reduced by “getting the general population to eat less and exercise more; reducing the incidence of drunk driving; increasing the use of seat belts, child restraints, and bicycle helmets; and reducing cardiovascular disease risk through aspirin, blood pressure control, cholesterol reduction, and smoking cessation.” Indeed, these interventions constitute a terrific research agenda! Why not devote more research funds to finding out how to make these interventions more efficient?
Michael J. Joyner, Nigel Paneth, John P. A. Ioannidis. Underperforming Big Ideas in Biomedical Research—Reply. JAMA. 2017;317(3):322. doi:10.1001/jama.2016.20003