Local application of the sulfonamide drugs in the management of various dermatologic and surgical conditions has by this time attained a deserved popularity. Sulfathiazole and its sodium salt, chiefly in crystalline or ointment form, have proved to be the most widely used and perhaps the most efficacious in this respect. Numerous reports attest both the popularity and the effectiveness of these medications when employed in the therapy of such diverse conditions as impetigo, ecthyma, pyoderma, furunculosis, certain cases of acne vulgaris, sycosis barbae, infectious eczematoid dermatitis and in secondarily infected cutaneous lesions of many other types.1 Certain ophthalmologic diseases have also been successfully treated by this method.2
Hypersensitivity to direct application of sulfathiazole to the skin has been encountered in isolated instances. The resultant reaction has been in the form of chemical, vesicular or vesiculopapular dermatitis at the onset. A systemic reaction has seldom been observed in this
WEINER AL. CUTANEOUS HYPERSENSITIVITY TO TOPICAL APPLICATION OF SULFATHIAZOLE. JAMA. 1943;121(6):411–413. doi:10.1001/jama.1943.02840060029007
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