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JAMA Clinical Guidelines Synopsis
February 28, 2017

Management of Sepsis and Septic Shock

Author Affiliations
  • 1Center for Healthcare Delivery Science and Innovation, University of Chicago, Chicago, Illinois
  • 2Pulmonary and Critical Care, University of Chicago, Chicago, Illinois
  • 3General Internal Medicine, University of Chicago, Chicago, Illinois
JAMA. 2017;317(8):847-848. doi:10.1001/jama.2017.0131

Sepsis results when the body’s response to infection causes life-threatening organ dysfunction. Septic shock is sepsis that results in tissue hypoperfusion, with vasopressor-requiring hypotension and elevated lactate levels.1 Sepsis is a leading cause of death, morbidity, and expense, contributing to one-third to half of deaths of hospitalized patients,2 depending on definitions.3 Management of sepsis is a complicated clinical challenge requiring early recognition and management of infection, hemodynamic issues, and other organ dysfunctions.