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The last forty years have seen great developments in rhinology. The first great advance followed the discovery of the medical uses of cocaine as a local astringent and anesthetic, and the form of practice was determined by anatomists and surgeons. The pronounced surgical point of view that arose developed its own evils, and it required the physiologist to correct errors resulting from behavior predicated on the idea that operative procedures were the chief reliance for the cure of many diseases of the nose.
Knowledge of normal function and behavior of the lining membrane of the nose and its accessory sinuses received its main impetus in this country from the studies of Proetz, Hilding and others. Medications freely used up to this time were found harmful to ciliary action of the cells of the mucosa of the nose. Oily preparations which had been widely favored were seen to carry the threat
Nasal Medication: A Practical Guide. JAMA. 1943;121(6):470. doi:10.1001/jama.1943.02840060088032
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