This paper is based on a study of 1,000 consecutive patients treated for varicose veins in the circulatory clinic of the Boston City Hospital from late in 1930 to the close of 1933. It includes many patients suffering from coexisting systemic diseases such as diabetes and syphilis, and diseases of the heart, lungs and kidneys. The study was undertaken to determine whether it is dangerous or unwise to treat such patients by the injection of sclerosing agents or by this injection plus the operation of ligation.
The literature is controversial on this subject. Of those taking a cautious attitude may be quoted de Takáts,1 Kilbourne,2 Beckman3 and McKinstry.4 The conditions that they list as contraindications to treatment are old age, simple debility added to old age, nephritis, heart disease, hypertension, diabetes, tuberculosis, hyperthyroidism, severe focal infection, and the common cold. De Takáts believes that the treatment
EDWARDS EA. THE TREATMENT OF VARICOSE VEINS: IS SYSTEMIC DISEASE A CONTRAINDICATION? JAMA. 1935;104(23):2077–2080. doi:10.1001/jama.1935.02760230025008
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