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June 8, 1935

Foreign Letters

JAMA. 1935;104(23):2107-2111. doi:10.1001/jama.1935.02760230055019

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LONDON  (From Our Regular Correspondent)May 11, 1935.

The Selenide Treatment of Metastases in Cancer of the Breast  The medical treatment of cancer has proved uniformly disappointing, but the recent work of Dr. A. T. Todd with selenium compounds seems to be of some promise and at present holds the field in this country. In a paper on "The Selenide Treatment of Mammary Metastases," read at the Section of Radiology of the Royal Society of Medicine, he argued that there was a defense mechanism in cancer resembling that in chronic infectious diseases. This mechanism was controlled by endothelial cells, which appeared to secrete substances that activated the rest of the tissue. These cells would take up any electro-negative colloid that came their way. If the colloid was of such a chemical nature that its breakdown simulated the metabolism of the cell, a greater defense would result. Some selenium colloids had

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