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The principle of equipoise states that, when there is uncertainty or conflicting expert opinion about the relative merits of diagnostic, prevention, or treatment options, allocating interventions to individuals in a manner that allows the generation of new knowledge (eg, randomization) is ethically permissible.1,2 The principle of equipoise reconciles 2 potentially conflicting ethical imperatives: to ensure that research involving human participants generates scientifically sound and clinically relevant information while demonstrating proper respect and concern for the rights and interests of study participants.1
London AJ. Equipoise in Research: Integrating Ethics and Science in Human Research. JAMA. 2017;317(5):525–526. doi:10.1001/jama.2017.0016
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