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Lab Reports
February 7, 2017

Father’s Age May Be a Factor in Neurodevelopmental Disorders

Author Affiliations

Copyright 2017 American Medical Association. All Rights Reserved.

JAMA. 2017;317(5):465. doi:10.1001/jama.2017.0113

New research in mice reveals that a mutation in a gene called Pax6 that plays a role in regulating neurodevelopment can have different effects when it is inherited from an older father vs a younger one.

In a PLOS ONEstudy, researchers from Japan and Italy examined the onset of behavioral abnormalities in mice carrying a particular mutation of Pax6. In humans, mutations in the PAX6 gene have been linked with autism spectrum disorders and related conditions, and several studies have demonstrated structural brain abnormalities in people with such mutations.