There is today much confusion on what constitutes the best method of treating cases of operable cancer of the female breast. A review of the literature throws little light on the subject because of the widely divergent points of view expressed. Unfortunately many opinions are given which are not based on pathologic studies and on careful follow-up physical examinations.
High voltage irradiation was introduced into the armamentarium of therapy about 1923 to 1925. Few clinics in America have had sufficient cases treated by the different methods made possible by varying combinations of surgery and high voltage irradiation, especially since the introduction of the so-called divided dose method by Coutard, to have come to a positive conclusion that would be above statistical errors.
In this report I review the operable cases treated by different methods in an effort to see if it is possible to arrive at a conclusion as to
ADAIR FE. THE ROLE OF SURGERY AND IRRADIATION IN CANCER OF THE BREAST. JAMA. 1943;121(8):553–559. doi:10.1001/jama.1943.02840080001001
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