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Article
June 15, 1935

THIOGLYCEROL: A MORE STABLE SULPHYDRYL COMPOUND FOR USE IN THE HEALING OF WOUNDS

Author Affiliations

SYRACUSE, N. Y.
From the Department of Surgery, Syracuse University College of Medicine.

JAMA. 1935;104(24):2168-2171. doi:10.1001/jama.1935.02760240028010
Abstract

Reimann1 in May 1930 reported relatively rapid healing of cutaneous ulcers by means of thiocresol. Later work by Reimann and others seems to confirm his observations. This paper offers observations based on animal experiments and 264 clinical cases treated with Thioglycerol. Thioglycerol seems to have certain advantages over other sulphydryl compounds that have been suggested for the stimulation of wound healing.

Hammett and Reimann,2 as a result of well controlled experiments on plants, rats and mice and finally on man, concluded that sulphur in the form of the chemical group sulphydryl (SH—) is an essential to cell production. Reimann3 also showed that animal skin could be thickened and the thickness of human skin grafts increased by the application of thiocresol, 0.25 per cent in hydrous wool fat. Birnbaum4 reported favorable results from the use of thiocresol on a variety of denuded surfaces and on skin grafts.

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