[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
February 27, 1943


Author Affiliations


From the Poliomyelitis Laboratory, Department of Epidemiology, Johns Hopkins University.

JAMA. 1943;121(9):662-664. doi:10.1001/jama.1943.02840090032009

The requirements for functional regeneration of divided nerves are complex and exacting. This is at once evident when it is realized that under the most favorable conditions of repair, by means of primary suture of accurately approximated stumps, the original function of the nerve is never completely restored. The many problems and clinical difficulties involved in connection with nerve injuries have been the subject of numerous investigations and publications, almost two thousand being cited by Pollock and Davis.1 Quite recently the experimental data and theoretical considerations on the long investigated problems of nerve regeneration have been reviewed critically and extensively by Young.2 Since an understanding of the complex series of processes which accompany unaided regeneration of severed nerves is basic for any consideration of methods of closure of gaps too wide to be bridged by the unassisted normal process, a brief summary of some of the essential details,