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February 27, 1943


JAMA. 1943;121(9):669-677. doi:10.1001/jama.1943.62840090004012

STATES OF AVITAMINOSIS  From the concept of deficiency states it may be seen that an avitaminosis includes all forms, degrees and stages. Under this classification the classic deficiency disease, as originally described, represents the severe acute state. Such a term as latent or subclinical state, which has been objectionable to some investigators, is no longer necessary. It is seen to be a broad state comprising the mild acute and mild chronic conditions. It is preferable to use the more specific designation corresponding to the actual condition. The severe chronic state has had no previous designation.The concept also explained the various courses in the pathogenesis of these states. Whereas the description thus far has indicated that any one of the several states exists alone, actually conditions are often more complex. Through the usual vicissitudes, particularly over years, the process usually changes in velocity, intensity and even direction. To mention one