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February 27, 1943


Author Affiliations

Welfare Island, New York.

JAMA. 1943;121(9):700-701. doi:10.1001/jama.1943.02840090070031

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To the Editor:—  I should like to call attention to the discussion of an article on page 1282 in the Dec. 19, 1942 issue entitled "Ochronosis of the Sclera and Cornea Complicating Alkaptonuria: The Literature; Report of Four Cases." In closing the discussion, Dr. Smith stated that "Sealock, Gladston [sic] and Steele have suggested that the continued high intake of vitamin C in early life may prevent the deposition of melanotic pigment in later years." We endeavored in the quoted article to express clearly the fact that our work had completely failed to suggest that vitamin C had any effect on the inborn error of metabolism known as alkaptonuria. We wished only to point out that our studies did not necessarily preclude this possibility. Our statement is as follows: "It should be pointed out that the large doses of ascorbic acid were without visible effect on the ochronosis exhibited by

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