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February 27, 1943

The Aromatic Amino and Nitro Compounds, Their Toxicity and Potential Dangers: A Review of the Literature

JAMA. 1943;121(9):711. doi:10.1001/jama.1943.02840090081038

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The extraordinary development of war industries in recent months has brought into sharp focus the need for detailed knowledge of the toxicology of the manifold chemical compounds used in present day manufacturing. In the present emergency many materials are being used both as solvents and as starting materials for chemical synthesis which have not been carefully scrutinized for possible deleterious action on workers. The hazard involved in the use of these compounds is enhanced by the pressure for production, which tends to minimize the use of peacetime precautions in the now crowded plants. Furthermore, certain solvents, degreasers and chemical reagents which had been restricted in use because of proved toxicity have appeared again because appropriate substitutes are not available in quantity.

Under these circumstances the present compilation of data on the aromatic amino and nitro compounds is peculiarly welcome. Published as a public health bulletin, this summary embodies a wide

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