This discussion deals, first, with a general evaluation of liver function tests and with the importance of adequate and carefully conducted normal control studies. In the second place, the comparative sensitivity and reliability of the newer tests, in relation to each other and to the older tests, as evaluated in a recent publication of ours,1 are reviewed and summarized. Finally, an improved bromsulphalein method has been developed, using 5 mg. of the dye per kilogram and employing a new time interval as the normal standard for complete disappearance of the dye from the blood stream.
GENERAL EVALUATION OF LIVER FUNCTION TESTS
Liver function tests offer valuable aid in the evaluation of hepatic cell function. However, these tests should be regarded only as an aid to clinical and other laboratory findings in the diagnosis of the exact pathologic conditions. Liver function tests indicate the existing functional state of
MATEER JG, BALTZ JI, MARION DF, MacMILLAN JM. LIVER FUNCTION TESTS: GENERAL EVALUATION OF LIVER FUNCTION TESTS, AND AN APPRAISAL OF THE COMPARATIVE SENSITIVITY AND RELIABILITY OF THE NEWER TESTS, WITH PARTICULAR EMPHASIS ON THE CEPHALINCHOLESTEROL FLOCCULATION TEST, THE INTRAVENOUS HIPPURIC ACID TEST AND AN IMPROVED BROMSULPHALEIN TEST WITH A NEW NORMAL STANDARD. JAMA. 1943;121(10):723–728. doi:10.1001/jama.1943.02840100009003
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