Textbooks of physiology and pathology as a rule have little to say about lymph in comparison with the elaborate discussions regarding blood. When one realizes that the blood vessels only rarely occur in immediate contact with the tissue cells it becomes clear that the fluid in the intervening spaces must be of considerable importance alike in the supply of nutrient substances and in the withdrawal of metabolic waste products. Lymph is regarded by many students as a fluid produced in certain regions at a more or less rapid rate by transudation from the blood vessels and carried back to the blood through well organized lymphatic vessels. There was a time when the fluid in the innumerable tissue spaces of the body was regarded as identical with the lymph of the lymphatic vessels. Presently, however, histologists insisted that the lymphatics are closed structures that have no direct connection with the tissue
LYMPH IS TISSUE FLUID. JAMA. 1931;97(2):104–105. doi:10.1001/jama.1931.02730020032013
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