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March 20, 1943


Author Affiliations


From the Neurological Service of Dr. I. S. Wechsler, Mount Sinai Hospital.

JAMA. 1943;121(12):914-916. doi:10.1001/jama.1943.02840120016004

In a previous article1 an attempt was made to determine the relationship, if any, between states of vitamin B1 deficiency and diabetic neuritis. For this purpose a quantitative study of the vitamin B1 content of the diet of patients with diabetic neuritis was made and found to be quite adequate, as judged by the Cowgill formula. The evidence, clinical and pathologic, in favor of a vascular etiology in diabetic neuritis was mentioned, but the possibility that avitaminosis nevertheless played a role in producing the neuritic syndrome was not ruled out, since defective absorption or utilization of the ingested vitamin had still to be considered. Further evaluation of these factors, it was stated at that time, was not feasible until tests for the metabolism of vitamin B1 had been elaborated. Since then such a test has been introduced, and the results it has yielded will be discussed