In a discussion of the toxicity of human plasma a few months ago,1The Journal called attention to the results of observations on the intravenous injection of unpooled plasma by Levine and State.2 Their work dealt with unpooled or monovalent plasma; the conclusion that there is "a correlation between skin sensitivity to the plasma and reactions after plasma transfusions" is not applicable therefore to pooled plasma. The authors themselves state that "it is not known what pooling of plasmas will do toward the elimination of transfusion reactions."
In the meantime the excellent results in the clinical use, without preliminary tests, of plasma indicate that pooling under standard requirements, perhaps by mere dilution, inactivates substances —antigens, haptens, antibodies—that may be present in individual samples of plasma. Possibly also the introduction from without of harmful substances is prevented by the method of preparing pooled plasma. It should not be overlooked
THE SAFETY OF POOLED HUMAN PLASMA. JAMA. 1943;121(12):946. doi:10.1001/jama.1943.02840120048013
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