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March 20, 1943


JAMA. 1943;121(12):946-947. doi:10.1001/jama.1943.02840120048014

A series of aromatic diamidines prepared by Ewins was found by Lourie and Yorke1 to possess activity against protozoal organisms as well as antimicrobic action. From the consideration of the chemical structure of these compounds it was expected that their antibacterial effect would not be inhibited by P-aminobenzoic acid as is the case with the sulfonamides. Thrower and Valentine2 point out that sulfathiazole in a minimal concentration of 1: 32,000 exerted an antibacterial effect and that this effect was completely inhibited by the addition of 1: 10,000 to 1: 1,000,000 of p-aminobenzoic acid. Propamidine, however, was unaffected by the p-aminobenzoic acid in the same dilutions and exerted an antibacterial effect at the minimal effective concentration of 1: 128,000 in both cases.

In vitro experiments indicated that 4:4' diamidinodiphenoxypropane dihydrochloride (propamidine) possesses a bacteriostatic activity against Staphylococcus aureus of the same order as sulfathiazole. The bactericidal activity of this