Since 1900 many investigators have studied patients during and after muscular work. Simonson and Enzer1 present an analytic review of such investigations of the gaseous exchange and the circulatory and respiratory functions. Distinctions between demonstrable fatigue and complaints of fatigue must be established by precise objective methods. Following analysis of the effect of disease on performance in various types of work, it might be possible to direct patients with chronic diseases toward occupations in which their working capacity would be least reduced. Control of the tax on their working capacity would be good therapy. Investigation during work permits a better understanding of the patient's actual condition than examination during rest. The patient may still be fully compensated while at rest but not for the increased demands during and immediately after muscular work. Thus the investigation of patients by means of exercise tests is especially important for those on the
MUSCULAR EXERCISE AND FATIGUE IN DISEASE. JAMA. 1943;121(13):1093–1094. doi:10.1001/jama.1943.02840130107014
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