At present, therapeutic experiments are carried out almost exclusively with two kinds of gonadotropic preparations, namely one prepared from the serum of pregnant mares and one derived from the urine of pregnant women.
In animal experiments the active principle prepared from the serum of pregnant mares—which in this paper will be designated as serum gonadotropin—has proved to stimulate the maturing of the ovarian follicles and to produce ovulation and the formation of corpus luteum.
The principle prepared from the urine of pregnant women appears to be formed in the placenta and will be designated as chorionic gonadotropin. In animal experiments its effect has differed with the species examined. From the observations reported so far it appears that chorionic gonadotropin in rodents, through cooperation with the pituitary of the animal, is able to produce a reaction similar to that obtained with serum gonadotropin. It is this effect that forms the basis
RYDBERG E, PEDERSEN-BJERGAARD K. EFFECT OF SERUM GONADOTROPIN AND CHORIONIC GONADOTROPIN ON THE HUMAN OVARY. JAMA. 1943;121(14):1117–1122. doi:10.1001/jama.1943.02840140001001
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