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Comment & Response
March 7, 2017

Sex and Gender Reporting in Research—Reply

Author Affiliations
  • 1Office of Research on Women’s Health, National Institutes of Health, Bethesda, Maryland
  • 2Institute of Gender and Health, Canadian Institutes of Health Research, Montreal, Canada
JAMA. 2017;317(9):975. doi:10.1001/jama.2017.0151

In Reply Biomedical research questions should be driven by substantive knowledge about biologic mechanisms, pathophysiology, and the risks of disease and treatment. There is strong indication that sex and gender matter for the majority of health conditions.1 Unfortunately, scientific discoveries remain hampered by systematic underinvestigation and underreporting of sex or gender across the spectrum of biomedical research from basic science to clinical trials.2,3