In Reply Biomedical research questions should be driven by substantive knowledge about biologic mechanisms, pathophysiology, and the risks of disease and treatment. There is strong indication that sex and gender matter for the majority of health conditions.1 Unfortunately, scientific discoveries remain hampered by systematic underinvestigation and underreporting of sex or gender across the spectrum of biomedical research from basic science to clinical trials.2,3
Clayton JA, Tannenbaum C. Sex and Gender Reporting in Research—Reply. JAMA. 2017;317(9):975. doi:10.1001/jama.2017.0151
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