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April 10, 1943

TOXICITY OF HUMAN PLASMA

Author Affiliations

S.W. London Blood Supply Depot, Benhill Avenue, Sutton, Surrey.

JAMA. 1943;121(15):1241. doi:10.1001/jama.1943.02840150055020

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Abstract

To the Editor:—  Our attention has been drawn to some inaccuracies in your editorial on Toxicity of Human Plasma (The Journal, Sept. 19, 1942, p. 206).In the first place you refer to the A and B group specific substances as haptens. There is now considerable evidence to show that they are antigens and not haptens. In the second place the statement that 50 per cent of group A and 85 per cent of group B serums contain the corresponding agglutinogen was qualified in our paper in the following way: "It should be mentioned here that the inhibition technic is not sufficiently sensitive to detect very small quantities of inhibiting substances" (J. Path. & Bact.54:92 [Jan.] 1942). "It is evident that amounts of agglutinogen too small to produce inhibition in vitro will yet produce a brisk response on injection. Although the inhibition test indicates that at least 50

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