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Comment & Response
March 14, 2017

Cranberry Capsules for Bacteriuria Plus Pyuria in Nursing Home Residents

Author Affiliations
  • 1Department of Food Science and Agricultural Chemistry, McGill University, Ste Anne de Bellevue, Quebec, Canada
  • 2Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Quebec, Canada
JAMA. 2017;317(10):1077-1078. doi:10.1001/jama.2017.0086

To the Editor The randomized clinical trial1 of cranberry capsules to prevent bacteriuria plus pyuria among older women in nursing homes found no significant differences between groups. However, 2 features of the study make the results less than definitive.

First, to assess how much an agent reduces recurrent urinary tract infections (UTIs), a population in which most of the participants have had recurrent infections should be targeted. However, about two-thirds (126 of 185) of the women participating in the study had not had a UTI in the year preceding the trial. Moreover, in the absence of the agent, less than one-third had a UTI in the course of the trial.