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To the Editor The randomized clinical trial1 of cranberry capsules to prevent bacteriuria plus pyuria among older women in nursing homes found no significant differences between groups. However, 2 features of the study make the results less than definitive.
First, to assess how much an agent reduces recurrent urinary tract infections (UTIs), a population in which most of the participants have had recurrent infections should be targeted. However, about two-thirds (126 of 185) of the women participating in the study had not had a UTI in the year preceding the trial. Moreover, in the absence of the agent, less than one-third had a UTI in the course of the trial.
Anderson C, McGregor K, Hanley JA. Cranberry Capsules for Bacteriuria Plus Pyuria in Nursing Home Residents. JAMA. 2017;317(10):1077–1078. doi:10.1001/jama.2017.0086
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