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Comment & Response
March 14, 2017

Cranberry Capsules for Bacteriuria Plus Pyuria in Nursing Home Residents

Author Affiliations
  • 1College of Pharmacy, University of Rhode Island, Kingston, Rhode Island
JAMA. 2017;317(10):1078. doi:10.1001/jama.2017.0089

To the Editor Dr Juthani-Mehta and colleagues1 evaluated the effects of cranberry proanthocyanidin (PAC) capsules (72 mg) vs placebo on bacteriuria plus pyuria in women residing in long-term care facilities.

Cranberry proanthocyanidins have long been viewed as the primary active component in cranberries associated with the prevention of UTIs. Evidence shows that PACs decrease the number and motility of the pathogenic Escherichia coli in the gut microbiome, which prevents colonization of the perineum and subsequently the urinary tract.2