To the Editor Dr Thompson’s article1 evaluated current evidence related to statin-associated adverse events. We note a common misinterpretation of the P value and its complement (1-P) in his discussion of the Effect of Statins on Skeletal Muscle Performance (STOMP) trial. He presented the results of a hypothesis test that assumed a null hypothesis of equal myalgia rates for statin and placebo populations. He correctly noted nonsignificance but concluded that statins caused myalgia symptoms with a probability of 0.946 (94.6%), essentially stating a posterior probability regarding the veracity of the alternative hypothesis that statins cause myalgia. It appears the latter assertion arose from subtracting the P value .054 (5.4%) from 1 (100%).
Malachowski SJ, Quattlebaum AM, Miladinovic B. Adverse Effects of Statins. JAMA. 2017;317(10):1079–1080. doi:10.1001/jama.2017.0148
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