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April 17, 1943

The Antigonadotropic Factor with Consideration of the Antihormone Problem

JAMA. 1943;121(16):1313. doi:10.1001/jama.1943.02840160063027

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The authors have chosen to discuss a controversial subject. The review is thorough and gives much data, pro and con, based on experimental evidence both animal and human. Historically, Long and Evans in 1921-1922 found that protracted treatment of female infantile rats with anterior pituitary extracts induced the formation of atretic corpora lutea, atrophy of the ovaries and failure of estrus. Zondek in 1930 reported that female animals subjected to prolonged treatment with gonotropic extract showed definite involution of the genital organs. In 1929 Lee, Teel and Gagnon reported failure of continued stimulation following prolonged treatment with thyrotropic factor. In 1934 Collip and Anderson postulated the presence of an antithyrotropic hormone. Since then antihormonal reactions have been reported for almost all the known hormones, especially those having a protein structure, such as the pituitary, the parathyroid, the adrenal and the pancreatic.

Zondek and Sulman state that "one of the main

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