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April 24, 1943

PERSONALITY CHANGES FOLLOWING SUBSTITUTION THERAPY IN PREADOLESCENT EUNUCHOIDISM

Author Affiliations

SAN FRANCISCO; MEDICAL CORPS, ARMY OF THE UNITED STATES

From the Departments of Psychiatry and Pathology, Mount Zion Hospital.

JAMA. 1943;121(17):1317-1321. doi:10.1001/jama.1943.02840170001001
Abstract

The dramatic physical changes resulting from the administration of testosterone and its derivatives to males with hypogonadism have been the subject of many reports since the introduction of this specific therapeutic agent.1 The anatomic and physiologic changes have received special attention, but the descriptions of the physiologic changes have with few exceptions been meager; in general, these factors have been overlooked.2 It is our purpose in this communication to present in greater detail the changes of personality that occurred following specific treatment in 7 cases of eunuchoidism.

The cases under observation represent moderate to severe types of hypogonadism that have been treated by the subcutaneous implantation of pellets of testosterone or its derivatives. In 3 cases previous therapy in the form of injections of testosterone propionate in oil had been given. Two types of pellets were used. Small pellets of methyl testosterone were prepared by compressing the crystalline

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