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April 24, 1943

ACUTE BACILLARY DYSENTERY (FLEXNER): TREATMENT WITH SULFAGUANIDINE AND SUCCINYLSULFATHIAZOLE

Author Affiliations

ELOISE, MICH.; LANSING, MICH.

From the William J. Seymour Hospital, Eloise, Mich., and the Bureau of Epidemiology, Michigan Department of Health, Lansing, Mich.

JAMA. 1943;121(17):1325-1330. doi:10.1001/jama.1943.02840170009003
Abstract

The control of acute bacillary dysentery is becoming increasingly important because of the presence of troops in tropical regions where this disease is common and also because of the poor housing and sanitary conditions which inevitably result from the mass shifting of civilian populations. During the past year numerous reports of the high incidence of this disease have come from the nations long at war; namely, China, Russia, Japan, Germany and Italy.

Uniformly favorable clinical results concerning the value of sulfaguanidine in the treatment of bacillary dysentery have been reported.1 There are, however, few published reports of the use of the newer sulfonamide compound succinylsulfathiazole in the treatment of this disease. This drug was first synthesized in 1939 by Miller, Rock and Moore2 and has been reported by Poth and Knotts and others3 to have striking bacteriostatic action against the usual intestinal flora of man and also

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