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April 24, 1943


Author Affiliations


From Sydenham Hospital, Baltimore City Health Department, and the Department of Pediatrics, Johns Hopkins University School of Medicine.

JAMA. 1943;121(17):1334-1337. doi:10.1001/jama.1943.02840170018006

In 1939 one of us1 reported 17 cases of pneumococcic meningitis treated with sulfapyridine at Sydenham Hospital between October 1938 and May 1939 with recovery of 8 patients (47 per cent). We have since then had occasion to treat 43 more patients at Sydenham Hospital and at the Harriet Lane Home of the Johns Hopkins Hospital. Since there is considerable variation in the mortality figures reported in case series from other hospitals2 it seemed to us worth while to report our own cases and analyze our experience.

Prior to the introduction of sulfonamide therapy the mortality in pneumococcic meningitis was nearly 99 per cent. The Goldsteins3 reviewed the literature in 1927 and were able to collect 150 authentic reports of recovery from this disease. Between 1930 and 1936 no specific therapy was used at Sydenham Hospital and all 29 patients died. From December 1936 to October 1938