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April 24, 1943


Author Affiliations

Boston Assistant in Neurology, Harvard Medical School, and Resident in Neurology, Boston City Hospital

From the Department of Neurology, Harvard Medical School, and the Neurological Unit, Boston City Hospital.

JAMA. 1943;121(17):1343-1344. doi:10.1001/jama.1943.62840170002008a

Direct injury to peripheral nerve trunks by deep intramuscular injection of drugs has been reported by many observers. Oppenheim1 in his Textbook of Nervous Diseases states that paralysis of the sciatic has been produced by the subcutaneous injections of ether, sublimate and antipyrine, and by the alcohol injections which were once used in the treatment of sciatica. Biggam2 and Seshachalam3 have found nerve damage due to quinine injection, and Gammel4 reported a case of peroneal nerve palsy after bismuth injection in the treatment of syphilis. Recently Elkington5 reported 2 cases of sciatic and one of radial nerve paralysis developing within a few days after deep injection of sodium sulfapyridine.

To my knowledge there has not been any reported case of injury to the sciatic nerve by paraldehyde. It is my purpose in this report to record 3 cases occurring within a brief period of time