Direct injury to peripheral nerve trunks by deep intramuscular injection of drugs has been reported by many observers. Oppenheim1 in his Textbook of Nervous Diseases states that paralysis of the sciatic has been produced by the subcutaneous injections of ether, sublimate and antipyrine, and by the alcohol injections which were once used in the treatment of sciatica. Biggam2 and Seshachalam3 have found nerve damage due to quinine injection, and Gammel4 reported a case of peroneal nerve palsy after bismuth injection in the treatment of syphilis. Recently Elkington5 reported 2 cases of sciatic and one of radial nerve paralysis developing within a few days after deep injection of sodium sulfapyridine.
To my knowledge there has not been any reported case of injury to the sciatic nerve by paraldehyde. It is my purpose in this report to record 3 cases occurring within a brief period of time
Woodson FG. SCIATIC NERVE INJURY DUE TO THE INTRAMUSCULAR INJECTION OF PARALDEHYDE. JAMA. 1943;121(17):1343–1344. doi:10.1001/jama.1943.62840170002008a
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: