I have studied lymphogranuloma venereum at the New York Hospital since 1932, largely in a clinic specially devoted to the disease. During that period Frei tests were performed on all inpatients and outpatients who presented symptoms or signs which were at the time regarded as lymphogranulomatous. The attendance of patients at the Lymphogranuloma Clinic was regular and extended, in most instances, over a period of years. The progress of clinical manifestations was closely followed by repeated proctoscopic and gynecologic examinations. From 1932 through 1937, treatment consisted chiefly of injections of antimony and potassium tartrate, fuadin, neostam and Frei antigen (by the intradermal and subcutaneous routes). As these remedies were virtually ineffective, the progress of the disease in the persons so treated must have differed little from that in untreated persons. Since 1938 therapy has been carried out mainly with the sulfonamide compounds, principally sulfathiazole and sulfanilamide.
Early in this study
GRACE AW. ANORECTAL LYMPHOGRANULOMA VENEREUM. JAMA. 1943;122(2):74–78. doi:10.1001/jama.1943.02840190004002
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