Many drugs and endocrine products which have been used for the purpose of inducing menstrual flow may be considered harmful when administered to a woman in whom amenorrhea is due to early pregnancy. At one time or another probably every obstetrician and gynecologist has experienced difficulty in distinguishing between delayed menstruation and early pregnancy by physical examination, especially when facilities for laboratory diagnostic procedures have not been available. After treating 57 cases of menstrual delay with prostigmine methylsulfate I have gained the impression that this drug offers a possible solution to both aforementioned problems in selected cases.
The rationale for prostigmine therapy in menstrual delay is found in the premise that, in the physiology of normal menstruation, the events which lead to the ultimate appearance of menstrual bleeding are initiated or at least preceded by a state of hyperemia of the uterine tissues. This hyperemia is always present in the
CARAPETYAN H. A COMBINED METHOD FOR THE TREATMENT OF DELAYED MENSTRUATION: AND A TEST FOR EARLY PREGNANCY: A PRELIMINARY REPORT. JAMA. 1943;122(2):81–83. doi:10.1001/jama.1943.02840190011004
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