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July 25, 1931


JAMA. 1931;97(4):228-230. doi:10.1001/jama.1931.02730040010003

Diphtheria toxoid (diphtheria anatoxin-Ramon) is coming into wide usage in the active immunization against diphtheria. This antigen has given uniformly good results with the production of complete immunity in a high percentage of persons. Ramon and Helie1 state that diphtheria anatoxin was widely used in the active immunization against diphtheria in France during 1924, 1925 and 1926, vaccination having been done on persons of all ages and in all walks of life. Thousands of children were immunized and the proportion rendered immune averaged from 90 to 95 per cent when two injections were used, and from 97 to 100 per cent with three injections. Equally good reports are beginning to appear in the American literature. The Dicks2 reported a comparative study of the effectiveness of diphtheria toxoid and toxin-antitoxin in a series of susceptible adults. They were able to immunize 94 per cent of 100 susceptible persons with