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May 8, 1943


JAMA. 1943;122(2):117. doi:10.1001/jama.1943.02840190047012

No doubt the discovery that sulfonamide compounds act locally as antiseptics served to revive the almost extinguished interest in local antisepsis. Of the newer antiseptics gramicidin and penicillin appear to possess a striking antiseptic action; the effect of propamidine in chronic wound infection was recently commented on in The Journal.1 In a recent issue of the British Medical Journal Browning2 calls attention anew to the flavines. As early as 1913 Browning and Gilmour demonstrated that the action of the diaminoacridine compounds, in contrast to all other efficient antiseptics, is intensified rather than reduced when the medium contains serum. Toxic damage from acriflavine or proflavine absorbed from wounds has not occurred. True necrosis may occur at the site of injection of flavines into closed tissues if the flavines are used in high concentrations. Russell and Falconer3 showed that 1: 1,000 solution of proflavine and 2: 7 diaminoacridine in