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July 25, 1931

HEMOPHILIA AND THE FEMALE SEX HORMONEPRELIMINARY REPORT

JAMA. 1931;97(4):244. doi:10.1001/jama.1931.02730040026009
Abstract

It has long been known that hemophilia exists only in males, while it is transmitted through the female. Although the female may transmit the disease to her sons, she shows no manifestation of the disease. If the female can transmit the disease, she must potentially have the disease and there must be something in the female organism which holds the disease in abeyance. Reasoning on this hypothesis, we treated two subjects having high grade hemophilia by ovarian therapy and ovarian transplant with excellent results.1

It has been proved by several investigators that the normal male is not pure male but is part female. It has also been definitely established that the female sex hormone can be isolated from the urine of normal males. As our hemophiliac subjects responded so well to ovarian therapy we thought it might be worth while to test the urine of such persons for the

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