Not long ago the newly recognized importance of cooling the body in shock was discussed in these columns.1 Refrigeration in conjunction with bloodlessness as an anesthetic in major amputations represents another application of crymotherapy. The fundamental work in the introduction of this form of anesthesia was done by Frederick M. Allen and his collaborators in the City Hospital of New York and experiments to extend the application are being continued in New York Medical College.2 The basic principles and the main results so far of the new method were reviewed by Allen and Crossman3 at the American Congress of Physical Therapy in Pittsburgh last December.
For some time it has been known that tissues can be kept alive for many days at ice box temperature provided they are not frozen. In experiments Allen has demonstrated that the cooling of limbs and other parts with ice water or ice, cracked or
REFRIGERATION ANESTHESIA IN MAJOR AMPUTATIONS. JAMA. 1943;122(3):177. doi:10.1001/jama.1943.02840200033010
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