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There is a large group of cases of food allergy in which the usual cutaneous tests do not aid in the diagnosis; many of the cases, in fact, present symptoms and syndromes which heretofore have not been recognized as allergic. These clinical conditions are herein grouped into a new category, which the author calls "familial nonreaginic food allergy," an unsatisfactory term offered only for the purpose of discussion and on the advice of a small group of allergists. Familial nonreaginic food allergy differs from the atopic category in that the hereditary influence is independent of the atopic inheritance, the allergic antibodies are not demonstrable as they are in the atopic group (bronchial asthma, hay fever and atopic dermatitis), many of the symptoms are not represented in the atopic group, and the allergic reaction practically always causes acceleration of the pulse rate. The importance of the new category is obvious in
Familial Nonreaginic Food-Allergy. JAMA. 1943;122(3):207. doi:10.1001/jama.1943.02840200063031
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