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July 25, 1931


JAMA. 1931;97(4):261-262. doi:10.1001/jama.1931.02730040043021

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Smallpox or Alastrim  In the agricultural bulletin of the Belgian Congo, Dr. Pigneur publishes a series of researches on the virus of alastrim. In the veterinary laboratory of Kisenyi, he performed a number of experiments to determine whether or not smallpox and alastrim constitute two different viruses.His first experiment was on a heifer, a sheep, a goat and a chicken. By superficial scarifications the virus of alastrim was introduced into the skin without result. Under the same conditions, all the animals reacted positively to the virus of smallpox.Second experiment: Calmette and Guérin had previously succeeded in provoking vaccinal immunity by the injection of cowpox subcutaneously. Pigneur used the same method for alastrim in a number of animals, which presented no reaction. The animals treated were inoculated, twenty days later, with cowpox, all with success.Third experiment: One of the natives attached to the vaccination service (who had been

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