The preparation of a highly concentrated and active form of penicillin was first reported by Chain, Florey and others1 in 1940. In 1941 Abraham and others2 reported more extensively on their investigative studies including the first clinical trials. They mentioned that the growth of six different strains of Neisseria gonorrheae was inhibited in dilutions in the order of 1:2,000,000. Another strain was inhibited only up to 1: 32,000. These investigators, however, pointed out that the actual figures reported must be taken with reserve because the potency of the penicillin varied as the work progressed. If the end point was based on twenty-four hour readings, the results may indeed vary considerably. Subsequent experience largely has confirmed this early work.3 Herein we report experimental and clinical results with Neisseria gonorrheae. While we have prepared small amounts of penicillin, the material used in our studies was furnished for the most
HERRELL WE, COOK EN, THOMPSON L. USE OF PENICILLIN IN SULFONAMIDE RESISTANT GONORRHEAL INFECTIONS. JAMA. 1943;122(5):289–292. doi:10.1001/jama.1943.02840220021005
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