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May 29, 1943


Author Affiliations

Bethesda, Md. Director, National Institute of Health.

JAMA. 1943;122(5):331. doi:10.1001/jama.1943.02840220063022

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To the Editor:—  My attention has been called to an article in The Journal (March 13, p. 828) entitled "Q Fever." Since the basis for the diagnosis of Q fever in this reported case was certain serologic tests done in this laboratory, I feel that two comments should be made: First, the diagnosis of Q fever was made on a complement fixation test the titer of which was only 1: 4. Those interested in this test at this laboratory feel that such a titer is not significant, particularly during the acute illness or early in the convalescence. Second, the article reports other serologic tests done at this laboratory but fails to mention that an agglutination of 1: 80 against Eberthella typhosa was obtained. This was on a sample of serum submitted on August 11, some two and one-half weeks after onset (July 25). In the case report there was no

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