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Article
May 29, 1943

IRRADIATION OF THE SPLEEN AND PITUITARY FOR CONTROL OF PUBERAL BLEEDING

Author Affiliations

Cincinnati.

JAMA. 1943;122(5):331-332. doi:10.1001/jama.1943.02840220063024

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Abstract

To the Editor:—  Some inaccuracies in the article by Dr. Ira I. Kaplan in The Journal of April 10 require comment and adjustment. Irradiation of the pituitary gland for the control of uterine bleeding in the adult was first advocated by me in 1922 and 1923 (Arch. f. Gynäk. 117:230, 120:194). This entirely new method was based on clinical and experimental evidence showing impairment of the development and the integrity of structure and function of the female generative tract as the result of destruction of the anterior lobe of the hypophysis or of damage to the midbrain. The fact that no harm may result from the application of properly screened hard roentgen rays to the brain of the adult emerged from the careful studies of Heineke, Lacassagne and Birch-Hirschfeld, while the investigations of Obersteiner revealed that the less resistant brain tissue of the adolescent organism may sustain microscopically

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