Over the past decade, scientific and public attention has focused on reports of an increased risk for autism spectrum disorder in children of depressed mothers treated with an antidepressant medication during pregnancy.1 However, evidence supporting an association between in utero exposure to antidepressant medications, especially selective serotonin reuptake inhibitors, and adverse long-term neurodevelopmental outcomes remains inconclusive.2 Methodological constraints limit the ability to account for the effect of variations in severity of maternal depression, and randomizing exposure to an antidepressant medication during pregnancy would not be ethical.
Oberlander TF, Zwaigenbaum L. Disentangling Maternal Depression and Antidepressant Use During Pregnancy as Risks for Autism in Children. JAMA. 2017;317(15):1533–1534. doi:10.1001/jama.2017.3414
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: