Heretofore it has been generally assumed, because of lack of convincing experimental evidence, that vitamin B produces growth entirely through its physiologic influence on stimulating the appetite and, conversely, it was postulated that all pathologic symptoms encountered in this avitaminosis are essentially those associated with inanition.1 Recently, Sure and Walker2 demonstrated that vitamin B, in addition to being an influencing factor in controlling the plane of nutrition, also exerts a specific effect on lactation, characterized by the growth and survival of nursing young, unrelated to food and water intake. We have now accumulated extensive data from numerous experiments substantiating our previous results on lactation and, in addition, have secured proof that vitamin B per se exerts an influence on the growth of the nonlactating albino rat. As little as 0.25 mg. daily of a highly concentrated vitamin B extract prepared by one of us (B. S.), introducing 0.125
SURE B, SMITH ME. AVITAMINOSISIII. SPECIFIC EFFECT OF VITAMIN B ON GROWTH AND LIPID METABOLISM: LIPEMIA AS A SYMPTOM COMPLEX IN THIS AVITAMINOSIS. JAMA. 1931;97(5):301–302. doi:10.1001/jama.1931.02730050009004
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